清末民初,佛山武学宗师黄飞鸿因噩梦预感女记者莫十三遇险,携弟子前往古云村寻人。村中蜈蚣教借蛊(gǔ )术(shù )胁(xié )迫(pò )村(cūn )民(mín )献祭孩童,莫十三探查真相时被擒,身中噬魂蛊。黄飞鸿闯祭坛救人,因不忍伤及被蛊惑的村民反中蛊毒,幸得卧底蜈蚣教的鬼脚七暗中相助。众人合(hé )力(lì )破(pò )除(chú )水(shuǐ )源(yuán )蛊(gǔ )毒(dú ),救(jiù )治(zhì )村(cūn )民(mín ),鬼(guǐ )脚七伤愈拜师。巫师自焚后,线索指向广州东瀛会馆。黄飞鸿潜入会馆救出被掳孩童,对决主事服部一郎,得知幕后(hòu )黑(hēi )手(shǒu )为(wéi )西(xī )洋(yáng )吸血鬼麦克罗。麦克罗散播疫毒祸乱羊城,以莫十三性命相要挟。黄飞鸿于绝境中融合腿法,悟出佛山无影脚,击杀麦克罗。蛊毒尽解,百姓恢复神智,广(guǎng )州(zhōu )重(chóng )归(guī )太(tài )平(píng ),宝(bǎo )芝(zhī )林(lín )重(chóng )回(huí )烟(yān )火日常。