清末民初,佛山武学宗师黄飞鸿因噩梦预感女记者莫十三遇险,携弟子前往古云(yún )村(cūn )寻(xún )人(rén )。村(cūn )中(zhōng )蜈(wú )蚣(gōng )教(jiāo )借(jiè )蛊(gǔ )术(shù )胁(xié )迫(pò )村民献祭孩童,莫十三探查真相时被擒,身中噬魂蛊。黄飞鸿闯祭坛救人,因不忍伤及被蛊惑的村民反中蛊毒,幸得(dé )卧(wò )底(dǐ )蜈(wú )蚣教的鬼脚七暗中相助。众人合力破除水源蛊毒,救治村民,鬼脚七伤愈拜师。巫师自焚后,线索指向广州东瀛会馆。黄飞鸿潜入会馆救出被掳孩童,对(duì )决(jué )主(zhǔ )事(shì )服(fú )部(bù )一(yī )郎(láng ),得(dé )知(zhī )幕(mù )后(hòu )黑(hēi )手(shǒu )为(wéi )西洋吸血鬼麦克罗。麦克罗散播疫毒祸乱羊城,以莫十三性命相要挟。黄飞鸿于绝境中融合腿法,悟出佛山无影脚(jiǎo ),击(jī )杀(shā )麦(mài )克罗。蛊毒尽解,百姓恢复神智,广州重归太平,宝芝林重回烟火日常。